Daniel Nadler | $1B+
Get in touch with Daniel Nadler | Daniel Nadler, founder and CEO of OpenEvidence, has emerged as one of the standout entrepreneurs of the AI era by building a platform that applies large language models to clinical decision-making and medical research. A former academic and founder of Kensho Technologies, which was acquired by S&P Global for $550 million, he has repeatedly operated at the intersection of artificial intelligence and high-value information systems. With OpenEvidence’s rapid growth among physicians, Nadler has become a major figure in AI-driven healthcare infrastructure.
Daniel Nadler (born 1983) is a Canadian-born entrepreneur and poet renowned for his pioneering work in artificial intelligence applications for finance and healthcare.[1]Nadler earned a Bachelor of Arts from the University of Toronto and a Ph.D. in political economy from Harvard University, where his thesis examined the political economy of federal systems during economic crises, particularly the influence of politics on financial markets post-2008; he also studied poetry under Pulitzer Prize-winner Jorie Graham during his time there.[1][2] In 2013, he cofounded Kensho Technologies, an AI firm specializing in financial intelligence, which raised significant funding including a $50 million Series B round in 2017 and was acquired by S&P Global for $550 million in 2018—the largest AI acquisition at the time.[1]In 2022, Nadler cofounded OpenEvidence, an AI-powered platform designed to help physicians navigate the overwhelming volume of medical research by synthesizing peer-reviewed studies in real time, often likened to "ChatGPT for doctors."[3] The company, which addresses the challenge of medical knowledge doubling every five years, has signed up over 430,000 doctors—about 40% of U.S. physicians—and is used to inform treatments for more than 50 million patients annually, particularly benefiting rural and underserved areas.[1][3][4] OpenEvidence raised $210 million in 2025 at a $3.5 billion valuation, later reaching $6 billion after a funding round co-led by GV (Google Ventures), propelling Nadler's net worth to $4.1 billion and earning him recognition in TIME's 2025 TIME100 Health list.[1][3]Beyond technology, Nadler is an accomplished poet whose work has been widely published and anthologized, including in Best American Experimental Writing; his debut collection, Lacunae, was published by Farrar, Straus and Giroux in 2016.[5] He divides his time between New York City, the West Coast, and Surfside, Florida, where he purchased a $38.2 million penthouse in 2025.[1]
Early life and education
Family background and early interests
Daniel Nadler was born and raised in Toronto, Ontario, Canada, as part of a family of post-World War II Eastern European immigrants.[4] His father hailed from Romania, while his mother was from Poland; his grandfather, a Holocaust survivor from Auschwitz, had initially sought refuge in the United States but settled in Canada after facing immigration barriers there.[4] This family history, marked by displacement and resilience, profoundly shaped Nadler's worldview, including his later focus on AI applications in healthcare to prevent errors like the medical mistake that claimed his grandfather's life.[4]From a young age, Nadler exhibited a fiercely competitive and intellectually curious nature, describing himself as a "total nerd" who joined Mensa and found traditional schooling unchallenging.[4] He engaged in memory games with friends, once challenging them to recite longer passages from Shakespeare's Hamlet soliloquy than he could.[4] These early pursuits in literature and mental acuity foreshadowed his lifelong blend of analytical rigor and creative expression, evident in his later studies of economics, poetry, and technology. Nadler's formative years in Toronto culminated in a Bachelor of Arts degree from the University of Toronto, paving the way for his advanced academic endeavors.[1]
Academic pursuits and degrees
Nadler earned a Bachelor of Arts degree from University College at the University of Toronto in 2005.[6][4]He pursued doctoral studies in political economy at Harvard University, completing his PhD in 2016.[1][7] His dissertation, titled The Political Economy of Federal Systems in Times of Economic Crisis, analyzed how political institutions mediate financial market responses to fiscal shocks, drawing on post-2008 crisis experiences in U.S. and German states to show that left-leaning political systems faced greater bond yield increases during credit seizures.[2] During his graduate work, Nadler co-authored influential papers on federalism and economic policy, including "Freedom to Fail: The Keystone of American Federalism" with Paul E. Peterson, published in the University of Chicago Law Review in 2011, which argued that U.S. federalism allows states to experiment with policy failures as a driver of innovation.[8] He also contributed to the 2014 Brookings Institution volume The Global Debt Crisis: Haunting U.S. and European Federalism, editing chapters on structural flaws in federal governance amid debt challenges.[9] Additionally, Nadler studied poetry under Pulitzer Prize-winning poet Jorie Graham, blending his interests in literature with rigorous quantitative analysis.[1] This foundation in econometric modeling of financial and political systems provided key insights for his later AI-driven ventures in natural language processing for complex data analysis.[1]
Professional career
Founding and leadership at Kensho Technologies
Daniel Nadler co-founded Kensho Technologies in May 2013 while pursuing his PhD in economics at Harvard University, alongside Peter Kruskall, who held a Master of Engineering from MIT.[10][11] The company was established in Harvard Square, Cambridge, Massachusetts, initially focusing on applying machine learning to analyze financial data, particularly the impacts of global events on markets. Nadler's inspiration stemmed from his time as a visiting scholar at the Boston Federal Reserve, where he observed the limitations of manual methods for tracking event-driven market reactions, such as central bank announcements or geopolitical developments.[12][13]As CEO, Nadler led Kensho's early growth by assembling a small team of experts and securing seed funding of $10 million shortly after founding, backed by Google Ventures and other investors. This capital enabled the recruitment of top engineering talent and the development of core technologies. Under his leadership, the company expanded its headquarters in Cambridge and pursued strategic funding rounds, including a Series B investment of $50 million in 2017 led by S&P Global, which valued Kensho at over $500 million and attracted participation from firms like J.P. Morgan and Morgan Stanley. These decisions positioned Kensho as a key player in AI-driven financial analytics, serving major Wall Street clients including global banks and hedge funds.[14][15]Kensho's innovations centered on AI systems that enabled natural language querying of complex financial datasets, generating original insights on event-market relationships—such as how airline stocks respond to natural disasters or defense equities to geopolitical tensions. Unlike traditional search tools, Kensho's machine learning platform processed unstructured data via natural language processing to produce visualized analyses, like graphs and charts, in seconds, a process that previously demanded hours of manual research. This democratized advanced market intelligence, initially targeted at institutional investors and later extended through media partnerships for broader access. Key milestones included launching analytics tools adopted by hedge funds for rapid event impact assessment and securing government contracts for similar applications, solidifying Kensho's reputation as a pre-LLM leader in AI for finance by 2017.[12][13]
Acquisition by S&P Global and subsequent roles
In 2018, S&P Global acquired Kensho Technologies for approximately $550 million in a deal comprising cash and stock, marking one of the largest acquisitions of an AI company at the time.[16] The strategic rationale centered on enhancing S&P Global's capabilities in artificial intelligence, natural language processing, and data analytics to deliver more actionable insights for financial markets, including improved risk assessment and market forecasting.[17] Post-acquisition, Kensho operated as an independent entity within S&P Global, retaining its brand and focusing on scaling AI technologies across the parent's financial services ecosystem, which immediately expanded access to vast proprietary datasets for machine learning applications.[18]Daniel Nadler continued as CEO of Kensho following the acquisition, reporting directly to Ewout Steenbergen, S&P Global's Chief Financial Officer, who oversaw enterprise-wide data and analytics initiatives.[19] In this role, Nadler led efforts to integrate Kensho's AI expertise with S&P Global's infrastructure, emphasizing the development of reusable machine learning tools to accelerate data onboarding and insight generation for clients in investment, credit risk, and competitive analysis.[20]A key early outcome was a collaborative project with Crunchbase, completed in under a month post-acquisition, where Kensho's machine learning algorithms linked private company data to S&P Global's Market Intelligence platform, enabling faster access to venture-stage insights for investment decisions and valuations.[20] Nadler highlighted this as a demonstration of the combined strengths, noting that the reusable technology would allow S&P Global to deliver complex datasets more rapidly than before.[20] Subsequent projects under Kensho's umbrella included Codex, a platform for searching financial documents with named entity recognition to support market forecasting, and Scribe, an AI tool for converting audio to structured text, enhancing risk assessment workflows across S&P Global's offerings.[21] These initiatives contributed to broader AI advancements, such as the 2024 launch of generative AI search capabilities on the S&P Global Marketplace, leveraging Kensho's foundational work since the acquisition.[22]Integration presented challenges, including scaling Kensho's technologies from a U.S.-centric startup model to S&P Global's multinational enterprise environment, such as synchronizing search engines like Omnisearch for global data handling and reliability testing across multiregion clusters.[21] This shift required adapting to enhanced resources while maintaining innovation, transitioning from rapid prototyping to production-hardened solutions that served over 150,000 users and supported SaaS delivery to financial clients.[21]
Establishment of OpenEvidence
In 2021, Daniel Nadler founded OpenEvidence, an AI startup focused on medical decision support, initially self-funding the venture before raising a friends-and-family round in 2023.[23] The company, co-founded with Zachary Ziegler as CTO, secured Series A funding led by Sequoia Capital in early 2025 at a $1 billion valuation, followed by a $210 million Series B round later that year co-led by Google Ventures and Kleiner Perkins, achieving a $3.5 billion valuation.[24][25] As founder and CEO, Nadler envisioned OpenEvidence as an AI copilot to address critical gaps in medical AI, such as information overload for clinicians amid rapidly expanding research, by enabling faster access to synthesized evidence at the point of care.[26][25]OpenEvidence's mission centers on organizing and expanding global medical knowledge to redefine evidence-based medicine in real time, ultimately improving patient outcomes through clinician empowerment.[27][25] Nadler emphasized ethical AI deployment in healthcare, prioritizing HIPAA compliance, transparency in sourcing, and grounding responses in verifiable evidence to minimize hallucinations common in general-purpose models.[25] The platform differentiates from Nadler's prior financial AI work at Kensho by pivoting to healthcare, leveraging similar natural language processing expertise but adapting it to domain-specific challenges like regulatory scrutiny and patient safety.[26]At its core, OpenEvidence employs large language models fine-tuned for healthcare queries, integrating advanced reasoning agents like DeepConsult™ to autonomously analyze and cross-reference peer-reviewed studies from sources such as PubMed, clinical trials, and guidelines.[28][25] Data sourcing relies on strategic partnerships, including full-text access to The New England Journal of Medicine, JAMA Network journals, and National Comprehensive Cancer Network guidelines, ensuring responses are cited and multimedia-enriched for physician usability.[24][27] This technology supports high-stakes decisions by synthesizing vast literature—scanning hundreds of studies in parallel—while promoting user adoption among verified U.S. physicians through free access and seamless integration into clinical workflows.[29][25]Early milestones include a beta phase emphasizing physician feedback, leading to widespread adoption: by mid-2025, over 40% of U.S. doctors used the platform daily, supporting more than 8.5 million monthly consultations across 10,000+ hospitals.[25][30] The 2025 wide release of DeepConsult™ marked a key advancement, earning OpenEvidence recognition as the fastest-growing physician app in history and Nadler a spot on TIME's 2025 Health 100 list.[25]In October 2025, OpenEvidence raised an additional $200 million in a Series C round led by Google Ventures, reaching a $6 billion valuation and supporting over 16 million clinical consultations per month as of that time.[31]
Creative and intellectual pursuits
Poetry and literary work
Daniel Nadler's debut poetry collection, Lacunae: 100 Imagined Ancient Love Poems, was published in 2016 by Farrar, Straus and Giroux.[32] The book consists of short, evocative poems that imagine translations of lost fragments from classical Indian manuscripts, exploring themes of love, absence, and the gaps in historical texts.[33] Nadler describes these works as filling invented or actual lacunae, creating a sequence of startling, minimalist verses that evoke ancient intimacy amid textual voids.[5] The collection was selected as one of NPR's Best Books of 2016.[34]Nadler's poetry has appeared in numerous literary journals and anthologies, including Boston Review, Conjunctions, and Colorado Review.[33][5] Excerpts from Lacunae were featured in Conjunctions:63, Callimachus (2015), where they contributed to experimental explorations of classical forms. His work has also been anthologized in Best American Experimental Writing (2016), highlighting his innovative approach to blending historical reconstruction with modern poetic brevity.[5] Over seventy of Nadler's poems have been published across various outlets, often delving into philosophical inquiries through fragmented, lyrical structures.[35]During his time at Harvard University, where he pursued studies in mathematics, classics, and poetry, Nadler was mentored by Pulitzer Prize-winning poet Jorie Graham, immersing himself in the Cambridge literary scene.[36] This period shaped his engagement with poetry as a rigorous intellectual pursuit, paralleling his academic interests in logic and ancient texts.[5] While specific fellowships or prizes for his poetry are not widely documented, Nadler's literary output has earned recognition for its fusion of scholarly precision and emotional resonance, as noted in reviews praising the collection's "poetics of vital import."[32]
Visual arts and interdisciplinary projects
Nadler maintains an active visual arts practice through his Daniel Nadler Workshop, where he produces digitally manipulated real-world photography and physical sculptures. His sculptural work integrates three-dimensional digital modeling with traditional techniques such as bronze casting and marble carving, creating unprecedented juxtapositions of modern and classical methods to evoke new visual realities.[37]In his photographic series, Nadler blends studio-captured portraits with those generated by artificial intelligence, exploring the boundaries between authentic imagery and algorithmic creation. This interdisciplinary approach merges visual art with emerging technologies, reflecting on the authenticity of images in the AI era. The series was featured in the 2022 Images Vevey Biennial in Vevey, Switzerland, where Nadler contributed to discussions on how AI-generated content introduces doubt into photographic interpretation.[38][37]Nadler's commitment to the arts is further evidenced by his election to the Board of Directors of MoMA PS1 in 2021, underscoring his role in supporting contemporary visual and interdisciplinary endeavors.
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